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Tissue invasive potential of Streptococcus mutans as shown by binding to oral mucosal tissues in situ
Umeå University, Faculty of Medicine, Department of Odontology, School of Dentistry.
2019 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Streptococcus mutans, which is the main bacterial cause of dental caries, expresses surface proteins Cnm and Cbm (collagen adhesin proteins) with specificity for collagen in addition to SpaP (surface protein adhesin) with specificity for salivary agglutinin/DMBT1. Cnm- and Cbm-positive strains of S. mutans have also been implicated in extraoral infections. The present study therefore investigated binding of Cnm- and Cbm-positive strains of S. mutans to oral mucosal tissues in situ. Fluorescence-labelled wildtype and mutant Cnm and Cbm S. mutans strains were tested for presence of binding to buccal mucosa in histological oral epithelial tissue sections at neutral (pH 7) and acidic (pH 2).

The results showed that both Cnm and Cbm strains bound to subepithelial but not to buccal epithelial tissues and that binding occurred both at pH 2 and 6. Neither epithelial nor subepithelial tissues bound SpaP-positive S. mutans strains devoid of Cnm or Cbm adhesins. In conclusion, our findings show avid binding of S. mutans to collagen-rich subepithelial tissues and thus suggest a tissue invasive potential of the organism.

Place, publisher, year, edition, pages
2019. , p. 12
Keywords [en]
Streptococcus mutans, adhesins, cnm, cbm, in situ
Keywords [sv]
Streptococcus mutans, adhesiner, cnm, cbm, in situ
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-157465OAI: oai:DiVA.org:umu-157465DiVA, id: diva2:1298125
Educational program
Dentistry Programme
Supervisors
Examiners
Available from: 2019-03-22 Created: 2019-03-21 Last updated: 2019-03-22Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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Language
  • de-DE
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  • en-US
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  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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  • asciidoc
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