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Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0002-6294-7844
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2019 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 18, no 3, p. 1208-1217Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e.g., skin, joints, kidneys, heart, and the central nervous system (CNS). SLE patients often have an overproduction of cytokines, e.g., interferons, chemokines, and interleukins. The high cytokine levels are part of the systemic inflammation, which can lead to tissue injury. In the present study, SLE patients were divided into five groups based on their autoantibody profiles. We thus defined these five groups: ANA negative, antiphospholipid (aPL) positive, anti-Sm/anti-RNP positive, Sjögren’s syndrome (SS) antigen A and B positive, and patients positive for more than one type of autoantibodies (other SLE). Cytokines were measured using Mesoscale Discovery (MSD) multiplex analysis. On the basis of the cytokine data, ANA negative patients were the most deviating subgroup, with lower levels of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-12/IL-23p40, and interferon gamma-induced protein (IP)-10. Despite low cytokine levels in the ANA negative group, autoantibody profiles did not discriminate between different cytokine patterns.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019. Vol. 18, no 3, p. 1208-1217
Keywords [en]
cytokine, HCA, multivariate data analysis, OPLS-DA, subgrouping, systemic lupus erythematosus
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-157770DOI: 10.1021/acs.jproteome.8b00811ISI: 000460491800035PubMedID: 30742448Scopus ID: 2-s2.0-85062355413OAI: oai:DiVA.org:umu-157770DiVA, id: diva2:1302072
Available from: 2019-04-03 Created: 2019-04-03 Last updated: 2019-04-03Bibliographically approved

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Torell, FridaTrygg, Johan

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