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Prediagnostic markers in late onset inflammatory bowel disease
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
2019 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 13, p. S186-S187Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background

We aimed to determine whether patients who later develop IBD show signs of inflammatory activity in blood measured with high-sensitivity CRP, calprotectin and albumin before clinical onset of inflammatory bowel disease (IBD).

Methods

We identified 96 subjects who participated in the heath survey ‘Northern Sweden Health and Disease Study’ and who later developed IBD (70 UC and 26 CD). High-sensitivity CRP, calprotectin and albumin was analysed in stored blood donated from cases and sex-age-matched controls 1 to 15 years before diagnosis.

Results

We found that subjects who later developed UC had lower albumin levels and subject who later developed CD had higher levels of CRP compared with the controls. Multi-variate conditional logistic regression with albumin, calprotectin and CRP showed a lower risk for developing IBD and UC with higher albumin levels (OR 0.789; CI 0.691–0.901 respective OR 0.773; CI 0.657–0.909). Higher CRP levels were associated with increased risk of developing CD (OR 1.314; CI 1.060–1.630). Adding BMI or smoking in the logistic regression model similar results was found. Serum calprotectin levels in the prediagnostic period in patients with IBD did not differ from controls.

Conclusions

This nested case–control study show that subjects who later develop IBD have signs of low-grade systemic inflammation years before the diseases become clinical. CRP and albumin was more sensitive to detect low-grade systemic inflammation than calprotectin.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2019. Vol. 13, p. S186-S187
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-157518DOI: 10.1093/ecco-jcc/jjy222.317ISI: 000460544501044OAI: oai:DiVA.org:umu-157518DiVA, id: diva2:1302727
Note

Supplement 1

Available from: 2019-04-05 Created: 2019-04-05 Last updated: 2019-04-05Bibliographically approved

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Lundgren, David

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CiteExportLink to record
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  • apa
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