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The prevalence of prolonged QTc increases by GOLD stage, and is associated with worse survival among subjects with COPD
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.ORCID iD: 0000-0002-2574-479x
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
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2019 (English)In: Heart & Lung, ISSN 0147-9563, E-ISSN 1527-3288, Vol. 48, no 2, p. 148-154Article in journal (Refereed) Published
Abstract [en]

Background: The role of QTc-prolongation, in relation to the increased mortality in COPD, is unclear.

Objectives: To estimate the prevalence and prognostic impact, assessed as mortality, of QTc-prolongation in COPD, restrictive spirometric pattern (RSP), and normal lung function (NLF), respectively.

Methods: All individuals (n = 993) with COPD and age- and sex-matched non-obstructive referents were identified from well-defined population-based cohorts examined in Northern Sweden in 2002–04. In 2005, the study-sample was invited to re-examination including ECG; QTc was calculated and mortality data collected until 31st December 2010.

Results: The prevalence of QTc-prolongation was higher among people with RSP than among those with NLF and, although similar in NLF and COPD, the prevalence increased by COPD-severity. Among participants with COPD, those with QTc prolongation had higher mortality than those with normal QTc, while no such differences were found among participants with NLF or RSP.

Conclusion: Among participants with COPD, the prevalence of QTc-prolongation increased by disease-severity and was associated with mortality.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 48, no 2, p. 148-154
Keywords [en]
Epidemiology, Comorbidity, Cardiology, Electrocardiogram, Pulmonary disease, Chronic obstructive
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-158114DOI: 10.1016/j.hrtlng.2018.09.015ISI: 000462808300013PubMedID: 30391074OAI: oai:DiVA.org:umu-158114DiVA, id: diva2:1304478
Funder
Swedish Heart Lung FoundationAvailable from: 2019-04-12 Created: 2019-04-12 Last updated: 2019-04-12Bibliographically approved

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Nilsson, UlfDiamant, Ulla-BrittBlomberg, AndersLindberg, Anne

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