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Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2019 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 500Article, review/survey (Refereed) Published
Abstract [en]

Peptidoglycan (PG) is an essential molecule for the survival of bacteria, and thus, its biosynthesis and remodeling have always been in the spotlight when it comes to the development of antibiotics. The peptidoglycan polymer provides a protective function in bacteria, but at the same time is continuously subjected to editing activities that in some cases lead to the release of peptidoglycan fragments (i.e., muropeptides) to the environment. Several soluble muropeptides have been reported to work as signaling molecules. In this review, we summarize the mechanisms involved in muropeptide release (PG breakdown and PG recycling) and describe the known PG-receptor proteins responsible for PG sensing. Furthermore, we overview the role of muropeptides as signaling molecules, focusing on the microbial responses and their functions in the host beyond their immunostimulatory activity.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, article id 500
Keywords [en]
peptidoglycan, PG cleaving enzymes, PG recycling, PG receptors, signaling functions, bacterial interactions
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-158090DOI: 10.3389/fmicb.2019.00500ISI: 000462687700001OAI: oai:DiVA.org:umu-158090DiVA, id: diva2:1304885
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationThe Kempe FoundationsAvailable from: 2019-04-15 Created: 2019-04-15 Last updated: 2019-04-15Bibliographically approved

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Hernandez, Sara B.Cava, Felipe

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Irazoki, OihaneHernandez, Sara B.Cava, Felipe
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