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Experimental evolution of novel regulatory activities in response to hydrocarbons and related chemicals
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Victoria Shingler)
2019 (English)In: Aerobic utililization of hydrocarbons, oils and Lipids. Handbook of hydrocarbon and lipid microbiology / [ed] Fernando Rojo, Cham: Springer, 2019, p. 737-749Chapter in book (Refereed)
Abstract [en]

Bacterial transcriptional regulatory proteins that control catabolism of hydrocarbons and related chemicals have evolved (or are actively evolving) toward specifically detecting compounds that signal the presence of growth substrates. Laboratory evolution of the chemical-binding and response properties of sensory regulators has been achieved by a number of different techniques to generate novel derivatives with desired properties. Such manipulated and selected regulatory proteins are increasingly used in artificial genetic circuitry for improved biodegradation systems, biosensor construction, and in assembling regulatory cascades for synthetic biology within a wide range of biotechnological applications.

Place, publisher, year, edition, pages
Cham: Springer, 2019. p. 737-749
Series
Handbook of hydrocarbon and lipid microbiology
National Category
Microbiology
Research subject
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-158264DOI: 10.1007/978-3-319-50418-6_34ISBN: 978-3-319-50417-9 (print)ISBN: 978-3-319-50418-6 (electronic)OAI: oai:DiVA.org:umu-158264DiVA, id: diva2:1305638
Funder
Swedish Research CouncilThe Kempe FoundationsAvailable from: 2019-04-17 Created: 2019-04-17 Last updated: 2019-04-17Bibliographically approved

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Shingler, Vicky

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