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Associations between brain volumes, myelin and upper-limb kinematics in children born preterm
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
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2019 (Engelska)Ingår i: Developmental Medicine & Child Neurology, ISSN 0012-1622, E-ISSN 1469-8749, Vol. 61, nr S2, s. 53-54, artikel-id OP 130Artikel i tidskrift, Meeting abstract (Refereegranskat) Published
Abstract [en]

Introduction: Long-term outcomes linked to preterm (PT) births have generally found an increased amount of neuromotor-developmental delays and/or disabilities. Few studies have addressed how upper-limb kinematics associates with brain volumes and myelination. This study aimed to investigate such possible relationships within children born PT compared with term-born controls at early school age, in relation to gestational age (GA) and birth-weight (BW).

Material and methods: This sub-study, part of a multidisciplinary project exploring long-term effects of PT births, included 27 children (Mean age= 8.2y) born PT (Mean GA= 32-weeks, range 22-35), and 33 age-matched born term. Kinematics of task-specific head and bi-/uni-manual upper-limb-movements was measured by a 3D-registration system (ProReflex). Brain volumes and myelin content were investigated by a 3-Tesla, magnetic resonance imaging (MRI)-scanner with a 7-min Synthetic MRI (SyMRI) acquisition-sequence.

Results: Significantly (p < .05) less efficient upper-limb kinematics with more segmented and longer movement paths was found in PT-born compared with term-born, particularly evident for those extremely-/very PT-born (<32 GA). Smaller total brain volumes and regional white-matter reduction with less myelin were significantly correlated with more segmented and longer arm- and head-trajectories, and with lower GA and BW.

Discussion-conclusion: The present findings show that an extremely- and very-PT-birth may cause long-term effects on neuromotor-mechanisms involved in goal-directed movements and that these effects are associated with generally delayed brain development and myelination. Additionally, SyMRI stands out as a suitable and cost-effective method for longitudinal/follow-up of brain development and changes, reducing distress in children due to a decreased scan time.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2019. Vol. 61, nr S2, s. 53-54, artikel-id OP 130
Nyckelord [en]
preterm, neuro-motor-mechanisms, myelin, SyMRI, kinematics
Nationell ämneskategori
Samhällsvetenskap Neurovetenskaper
Forskningsämne
psykologi; pediatrik; radiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-159820DOI: 10.1111/dmcn.14244OAI: oai:DiVA.org:umu-159820DiVA, id: diva2:1321646
Forskningsfinansiär
Vetenskapsrådet, 2011-179Tillgänglig från: 2019-06-09 Skapad: 2019-06-09 Senast uppdaterad: 2019-06-13Bibliografiskt granskad

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Domellöf, ErikJohansson, Anna-MariaRiklund, KatrineLenfeldt, Niklas

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Rönnqvist, LouiseDomellöf, ErikJohansson, Anna-MariaRiklund, KatrineLenfeldt, Niklas
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Institutionen för psykologiInstitutionen för strålningsvetenskaperInstitutionen för farmakologi och klinisk neurovetenskap
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Developmental Medicine & Child Neurology
SamhällsvetenskapNeurovetenskaper

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