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Circulating tumor cells mirror bone metastatic phenotype in prostate cancer
Sahlgrenska Cancer Center, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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2018 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 9, no 50, p. 29403-29413Article in journal (Refereed) Published
Abstract [en]

Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer.

Place, publisher, year, edition, pages
2018. Vol. 9, no 50, p. 29403-29413
Keywords [en]
circulating tumor cells, liquid biopsies, skeletal metastases of prostate cancer
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:umu:diva-159988DOI: 10.18632/oncotarget.25634PubMedID: 30034626OAI: oai:DiVA.org:umu-159988DiVA, id: diva2:1322910
Available from: 2019-06-11 Created: 2019-06-11 Last updated: 2019-06-13Bibliographically approved

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Josefsson, Andreas

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CiteExportLink to record
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  • apa
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