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Peri-implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri-implantitis
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-4430-8125
Umeå University, Faculty of Medicine, Department of Odontology. Department of Periodontology, Public Dental Health County Council of Gävleborg, Gävle County Hospital, Gävle, Sweden; Center for Clinical Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.ORCID iD: 0000-0002-5327-8028
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-8244-5200
2019 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 46, no 6, p. 669-677Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study was to explore which peri‐implant crevicular fluid (PICF) protein pattern is associated with the active peri‐implantitis process.

Materials and methods: Peri‐implant crevicular fluid from 25 peri‐implantitis sites were subjected to proteomic analysis using liquid chromatography–tandem mass spectrometry before and at 3, 6 and 12 months after treatment, to identify associations between PICF protein pattern and implant loss, bleeding on probing, pocket depth and enamel matrix derivative (EMD) treatment.

Results: Clustering of subjects based on their 3–12 months PICF proteomic profiles by principal component analysis defined two major clusters. Cluster 2 differentiated from cluster 3 by 52 proteins (R2 = 90%, Q2 = 80%) and belonging to cluster 2 was associated with implant loss (p = 0.009) and bleeding on probing (p = 0.001). Cluster 3 was associated with implant survival and EMD treatment (p = 0.044).

Conclusion: Here, we demonstrate that a specific PICF proteomic profile associates with active peri‐implantitis process and implant loss.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 46, no 6, p. 669-677
Keywords [en]
enamel matrix derivative, implant, peri-implantitis, proteome
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-159844DOI: 10.1111/jcpe.13108ISI: 000468314400008PubMedID: 30985016OAI: oai:DiVA.org:umu-159844DiVA, id: diva2:1323085
Available from: 2019-06-11 Created: 2019-06-11 Last updated: 2019-06-11Bibliographically approved

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Esberg, AndersIsehed, CatrineLundberg, Pernilla

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