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The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0002-1269-8288
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2019 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 12, no 581, article id eaax3521Article in journal, Editorial material (Other academic) Published
Abstract [en]

Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.

Place, publisher, year, edition, pages
Washington: American Association for the Advancement of Science , 2019. Vol. 12, no 581, article id eaax3521
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Cell Biology
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URN: urn:nbn:se:umu:diva-159599DOI: 10.1126/scisignal.aax3521ISI: 000467963000003PubMedID: 31088977OAI: oai:DiVA.org:umu-159599DiVA, id: diva2:1325795
Available from: 2019-06-17 Created: 2019-06-17 Last updated: 2019-06-17Bibliographically approved

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Gekara, Nelson O.Jiang, Hui

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