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Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Department of Physics and Technology, University of Bergen, Bergen, Norway.ORCID iD: 0000-0002-1645-0810
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2019 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 60, no 6, p. 788-797Article in journal (Refereed) Published
Abstract [en]

Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US).

Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human prostate cancer, and their relationship to dose deposition and time-frame after treatment. A special focus has been placed to evaluate the vascular heterogeneity of the tumor and on the most suitable data analysis approach that reflects this heterogeneity.

Material and Methods: In vivo DCE-US was acquired 24 h and 48 h after radiation treatment with a single dose of 7.5 Gy and 10 Gy, respectively. Tumor vasculature was characterized pixelwise using the Brix pharmacokinetic analysis of the time-intensity curves.

Results: Longitudinal changes were detected (P < 0.001) at 24 h and 48 h after treatment. At 48 h, the eliminating rate constant of the contrast agent from the plasma, kel, was correlated (P ≤ 0.05) positively with microvessel density (MVD; rτ = 0.7) and negatively with necrosis (rτ = –0.6) for the treated group. Furthermore, Akep, a parameter related to transcapillary transport properties, was also correlated to MVD (rτ = 0.6, P ≤ 0.05).

Conclusion: DCE-US has been shown to detect vascular changes at a very early stage after radiotherapy, which is a great advantage since DCE-US is non-invasive, available at most hospitals, and is low in cost compared to other techniques used in clinical practice.

Place, publisher, year, edition, pages
Sage Publications, 2019. Vol. 60, no 6, p. 788-797
Keywords [en]
Dynamic contrast-enhanced ultrasound, DCE-US, ultrasound, CWR22, prostate, cancer
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-160290DOI: 10.1177/0284185118798167ISI: 000469519900015PubMedID: 30231620OAI: oai:DiVA.org:umu-160290DiVA, id: diva2:1326039
Available from: 2019-06-17 Created: 2019-06-17 Last updated: 2019-06-17Bibliographically approved

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Arteaga-Marrero, Natalia

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