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Saliva and Serum Immune Responses in Apical Periodontitis
University of Helsiki, Finland.
University of Helsiki, Finland.
University of Oulu, Finland.
Karolinska Institutet, Sweden.
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2019 (Engelska)Ingår i: Journal of clinical medicine, ISSN 2077-0383, Vol. 8, nr 6, artikel-id 889Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01-8.33) and 4.91 (2.48-9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48-2.97)), serum IgG to bacterial antigens (4.66 (1.22-10.1)), and Gram-negative subgingival species (1.98 (1.16-3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05-21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis-a putative risk factor for systemic diseases.

Ort, förlag, år, upplaga, sidor
Basel, Switzerland: MDPI, 2019. Vol. 8, nr 6, artikel-id 889
Nyckelord [en]
adaptive immunity, antibody, apical periodontitis, saliva, serum
Nationell ämneskategori
Klinisk medicin
Forskningsämne
immunologi
Identifikatorer
URN: urn:nbn:se:umu:diva-161062DOI: 10.3390/jcm8060889ISI: 000475349300133PubMedID: 31234349OAI: oai:DiVA.org:umu-161062DiVA, id: diva2:1331640
Tillgänglig från: 2019-06-27 Skapad: 2019-06-27 Senast uppdaterad: 2019-08-12Bibliografiskt granskad

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