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Serum Metabolite Markers of Dementia Through Quantitative NMR Analysis: The Importance of Threonine-Linked Metabolic Pathways
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.ORCID iD: 0000-0001-8819-2278
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
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2019 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 69, no 3, p. 763-774Article in journal (Refereed) Published
Abstract [en]

There is a great need for diagnostic biomarkers of impending dementia. Metabolite markers in blood have been investigated in several studies, but inconclusive findings encourage further investigation, particularly in the pre-diagnostic phase. In the present study, the serum metabolomes of 110 dementia or pre-diagnostic dementia individuals and 201 healthy individuals matched for age, gender, and education were analyzed by nuclear magnetic resonance spectroscopy in combination with multivariate data analysis. 58 metabolites were quantified in each of the 311 samples. Individuals with dementia were discriminated from controls using a panel of seven metabolites, while the pre-diagnostic dementia subjects were distinguished from controls using a separate set of seven metabolites, where threonine was a common significant metabolite in both panels. Metabolite and pathway alterations specific for dementia and pre-diagnostic dementia were identified, in particular a disturbed threonine catabolism at the pre-diagnostic stage that extends to several threonine-linked pathways at the dementia stage.

Place, publisher, year, edition, pages
IOS Press, 2019. Vol. 69, no 3, p. 763-774
Keywords [en]
Alzheimer's disease, biomarker, dementia, metabolomics/metabonomics, NMR, serum, vascular dementia
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-161551DOI: 10.3233/JAD-181189ISI: 000471781600013PubMedID: 31127768OAI: oai:DiVA.org:umu-161551DiVA, id: diva2:1336833
Funder
Knut and Alice Wallenberg FoundationThe Kempe FoundationsAvailable from: 2019-07-10 Created: 2019-07-10 Last updated: 2019-07-10Bibliographically approved

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Figueira, JoaoAdolfsson, RolfNordin Adolfsson, AnnelieNyberg, LarsÖhman, Anders

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Figueira, JoaoAdolfsson, RolfNordin Adolfsson, AnnelieNyberg, LarsÖhman, Anders
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Department of Pharmacology and Clinical NeurosciencePsychiatryDepartment of Radiation SciencesDepartment of Integrative Medical Biology (IMB)
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Journal of Alzheimer's Disease
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