Serum Metabolite Markers of Dementia Through Quantitative NMR Analysis: The Importance of Threonine-Linked Metabolic PathwaysVisa övriga samt affilieringar
2019 (Engelska)Ingår i: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 69, nr 3, s. 763-774Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
There is a great need for diagnostic biomarkers of impending dementia. Metabolite markers in blood have been investigated in several studies, but inconclusive findings encourage further investigation, particularly in the pre-diagnostic phase. In the present study, the serum metabolomes of 110 dementia or pre-diagnostic dementia individuals and 201 healthy individuals matched for age, gender, and education were analyzed by nuclear magnetic resonance spectroscopy in combination with multivariate data analysis. 58 metabolites were quantified in each of the 311 samples. Individuals with dementia were discriminated from controls using a panel of seven metabolites, while the pre-diagnostic dementia subjects were distinguished from controls using a separate set of seven metabolites, where threonine was a common significant metabolite in both panels. Metabolite and pathway alterations specific for dementia and pre-diagnostic dementia were identified, in particular a disturbed threonine catabolism at the pre-diagnostic stage that extends to several threonine-linked pathways at the dementia stage.
Ort, förlag, år, upplaga, sidor
IOS Press, 2019. Vol. 69, nr 3, s. 763-774
Nyckelord [en]
Alzheimer's disease, biomarker, dementia, metabolomics/metabonomics, NMR, serum, vascular dementia
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:umu:diva-161551DOI: 10.3233/JAD-181189ISI: 000471781600013PubMedID: 31127768Scopus ID: 2-s2.0-85067103997OAI: oai:DiVA.org:umu-161551DiVA, id: diva2:1336833
Forskningsfinansiär
Knut och Alice Wallenbergs StiftelseKempestiftelserna2019-07-102019-07-102023-03-24Bibliografiskt granskad