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Immunoscore, circulating tumor cells and human-derived organoids as potential predictive tools in personalized cancer medicine
Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
2017 (English)In: Medical ethics, prediction, and prognosis: interdisciplinary perspectives / [ed] Mariacarla Gadebusch Bondio, Francesco Spöring, and John-Stewart Gordon, United Kingdom: Routledge, 2017, p. 175-185Chapter in book (Other academic)
Abstract [en]

In order to validate the immunoscore, an international consortium with twenty-three centers involved was initiated in 2012. It is planned to test immunoscore on tumor samples from several thousand colorectal cancer patients. Observations from tumor immunology have contributed to the findings that immune cell type, density, and location within the tumor could be a prognostic factor, and have thus led to the development of the immunoscore. The tumor cells that are present in the bloodstream are called circulating tumor cells, and are believed to be the direct precursors of the metastases. The tumor staging system staging system is based on the analysis of tumor burden, presence of cancer cells in lymph nodes, and distant metastasis, thus focusing mainly on tumor cells. During the equilibrium phase, which is typically the phase when the cancer is diagnosed in the patients, immune cells are still capable of eliminating tumor cells, but are unable to completely eradicate the tumor cells.

Place, publisher, year, edition, pages
United Kingdom: Routledge, 2017. p. 175-185
Series
Routledge Annals of Bioethics
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-161671DOI: 10.4324/9781315208084-14ISBN: 9781138632691 (print)ISBN: 9781315208084 (electronic)OAI: oai:DiVA.org:umu-161671DiVA, id: diva2:1338577
Available from: 2019-07-23 Created: 2019-07-23 Last updated: 2019-08-23

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Pastula, Agnieszka

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