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Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0001-8540-6891
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2019 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 188, no 6, p. 1055-1065Article in journal (Refereed) Published
Abstract [en]

The biological mechanisms driving associations between alcohol consumption and chronic diseases might include epigenetic modification of DNA methylation. We explored the hypothesis that alcohol consumption is associated with methylation in an epigenome-wide association study of blood and normal breast tissue DNA. Infinium HumanMethylation450 BeadChip (Illumina Inc., San Diego, California) array data on blood DNA methylation was examined in a discovery set of 2,878 non-Hispanic white women from the Sister Study (United States, 2004-2015) who provided detailed questionnaire information on lifetime alcohol use. Robust linear regression modeling was used to identify significant associations (false discovery rate of Q < 0.05) between the number of alcoholic drinks per week and DNA methylation at 5,458 cytosine-phosphate-guanine (CpG) sites. Associations were replicated (P < 0.05) for 677 CpGs in an independent set of 187 blood DNA samples from the Sister Study and for 628 CpGs in an independent set of 171 normal breast DNA samples; 1,207 CpGs were replicated in either blood or normal breast, with 98 CpGs replicated in both tissues. Individual gene effects were notable for phosphoglycerate dehydrogenase (PGHDH), peptidyl-prolyl cis-trans isomerase (PPIF), solute carrier 15 (SLC15), solute carrier family 43 member 1 (SLC43A1), and solute carrier family 7 member 11 (SLC7A11). We also found that high alcohol consumption was associated with significantly lower global methylation as measured by the average of CpGs on the entire array.

Place, publisher, year, edition, pages
Oxford University Press, 2019. Vol. 188, no 6, p. 1055-1065
Keywords [en]
alcohol consumption, breast cancer, DNA methylation, epigenome-wide association study
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-161732DOI: 10.1093/aje/kwz032ISI: 000473760200008PubMedID: 30938765OAI: oai:DiVA.org:umu-161732DiVA, id: diva2:1339172
Available from: 2019-07-26 Created: 2019-07-26 Last updated: 2019-07-26Bibliographically approved

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Harlid, Sophia

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