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Adiposity Mediates the Association between the Dietary Inflammatory Index and Markers of Type 2 Diabetes Risk in Middle-Aged Black South African Women
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.ORCID-id: 0000-0001-7768-1076
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2019 (Engelska)Ingår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, nr 6, artikel-id 1246Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The dietary inflammatory index (DII®), a validated tool used to measure the inflammatory potential of the diet, has been associated with metabolic disorders in various settings, but not in African populations. The aim of this study was to investigate whether the DII is associated with markers of type 2 diabetes (T2D) risk, and if this association is mediated by adiposity and/or low-grade inflammation, in black South Africa women. Energy-adjusted-DII (E-DII) scores were calculated in 190 women (median age, 53 years) from the Birth-to-Twenty plus cohort using a validated food frequency questionnaire. Fasting glucose, insulin, HbA1c, and inflammatory cytokines were measured, and an oral glucose tolerance test performed. Basic anthropometry and dual-energy x-ray absorptiometry-derived body fat, including estimate of visceral adipose tissue (VAT) area, were measured. E-DII scores were associated with all markers of T2D risk, namely, fasting glucose and insulin, HbA1c, HOMA2-IR, two-hour glucose and Matsuda index (all p < 0.05). After adjusting for age, measures of adiposity, but not inflammatory cytokines, mediated the association between E-DII and markers of T2D risk (p < 0.05). Measures of central obesity had proportionally higher (range: 23.5–100%) mediation effects than total obesity (range: 10–60%). The E-DII is associated with T2D risk through obesity, in particular central obesity, among black middle-aged South African women.

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MDPI, 2019. Vol. 11, nr 6, artikel-id 1246
Nyckelord [en]
DII, diet-induced inflammation, obesity, VAT, mediation, T2D risk, South African women
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URN: urn:nbn:se:umu:diva-161928DOI: 10.3390/nu11061246ISI: 000474936700052PubMedID: 31159253Scopus ID: 2-s2.0-85067181094OAI: oai:DiVA.org:umu-161928DiVA, id: diva2:1340751
Tillgänglig från: 2019-08-06 Skapad: 2019-08-06 Senast uppdaterad: 2019-08-06Bibliografiskt granskad

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Chorell, ElinOlsson, Tommy

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Micklesfield, Lisa K.Chorell, ElinOlsson, TommyHebert, James R.
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