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Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
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2019 (English)In: Molecular Nutrition & Food Research, ISSN 1613-4125, E-ISSN 1613-4133, Vol. 63, no 9Article in journal (Refereed) Published
Abstract [en]

ScopeSmall selenium (Se) species play a key role in Se metabolism and act as dietary sources of the essential trace element. However, they are redox-active and trigger pro- and antioxidant responses. As health outcomes are strongly species-dependent, species-specific characteristics of Se compounds are tested in vivo. Methods and resultsIn the model organism Caenorhabditis elegans (C. elegans), immediate and sustained effects of selenite, selenomethionine (SeMet), and Se-methylselenocysteine (MeSeCys) are studied regarding their bioavailability, incorporation into proteins, as well as modulation of the cellular redox status. While all tested Se compounds are bioavailable, only SeMet persistently accumulates and is non-specifically incorporated into proteins. However, the protection toward chemically-induced formation of reactive species is independent of the applied Se compound. Increased thioredoxin reductase (TXNRD) activity and changes in mRNA expression levels of antioxidant proteins indicate the activation of cellular defense mechanisms. However, in txnrd-1 deletion mutants, no protective effects of the Se species are observed anymore, which is also reflected by differential gene expression data. ConclusionSe species protect against chemically-induced reactive species formation. The identified immediate and sustained systemic effects of Se species give rise to speculations on possible benefits facing subsequent periods of inadequate Se intake.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 63, no 9
Keywords [en]
antioxidant defense systems, caenorhabditis elegans, selenium, oxidative stress, selenoproteins
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-162022DOI: 10.1002/mnfr.201801304ISI: 000476955800008PubMedID: 30815971OAI: oai:DiVA.org:umu-162022DiVA, id: diva2:1341928
Available from: 2019-08-12 Created: 2019-08-12 Last updated: 2019-08-12Bibliographically approved

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Tuck, Simon

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