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The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by BDNF and KIBRA Polymorphisms
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
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2019 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, Vol. 31, no 9, p. 1422-1429Article in journal (Refereed) Published
Abstract [en]

Episodic memory is a polygenic trait influenced by different molecular mechanisms. We used PET and a candidate gene approach to investigate how individual differences at the molecular level translate into between-person differences in episodic memory performance of elderly persons. Specifically, we examined the interactive effects between hippocampal dopamine D2 receptor (D2DR) availability and candidate genes relevant for hippocampus-related memory functioning. We show that the positive effects of high D2DR availability in the hippocampus on episodic memory are confined to carriers of advantageous genotypes of the brain-derived neurotrophic factor (BDNF, rs6265) and the kidney and brain expressed protein (KIBRA, rs17070145) polymorphisms. By contrast, these polymorphisms did not modulate the positive relationship between caudate D2DR availability and episodic memory.

Place, publisher, year, edition, pages
MIT Press, 2019. Vol. 31, no 9, p. 1422-1429
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-162391DOI: 10.1162/jocn_a_01429ISI: 000477974100012PubMedID: 31112471Scopus ID: 2-s2.0-85070257740OAI: oai:DiVA.org:umu-162391DiVA, id: diva2:1344252
Available from: 2019-08-20 Created: 2019-08-20 Last updated: 2019-08-20Bibliographically approved

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Karalija, NinaSalami, AlirezaAndersson, MicaelAxelsson, JanRiklund, KatrineNyberg, Lars

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Karalija, NinaSalami, AlirezaAndersson, MicaelAxelsson, JanRiklund, KatrineNyberg, Lars
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Department of Integrative Medical Biology (IMB)Radiation PhysicsDepartment of Radiation Sciences
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