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Investigating tissue bioconcentration and the behavioural effects of two pharmaceutical pollutants on sea trout (Salmo trutta) in the laboratory and field
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.ORCID iD: 0000-0001-5426-9652
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0002-3949-7371
Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.
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2019 (English)In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 207, p. 170-178Article in journal (Refereed) Published
Abstract [en]

Pharmaceuticals entering aquatic ecosystems via wastewater effluents are of increasing concern for wild animals. Because some pharmaceuticals are designed to modulate human behaviour, measuring the impacts of exposure to pharmaceuticals on fish behaviour has become a valuable endpoint. While laboratory studies have shown that pharmaceuticals can affect fish behaviour, there is a lack of understanding if behaviour is similarly affected in natural environments. Here, we exposed sea trout (Salmo trutta) smolts to two concentrations of two pharmaceutical pollutants often detected in surface waters: temazepam (a benzodiazepine, anxiolytic) or irbesartan (an angiotensin II receptor blocker, anti-hypertensive). We tested the hypothesis that changes to behavioural traits (anxiety and activity) measured in laboratory trials following exposure are predictive of behaviour in the natural environment (downstream migration). Measures of anxiety and activity in the laboratory assay did not vary with temazepam treatment, but temazepam-exposed fish began migrating faster in the field. Activity in the laboratory assay did predict overall migration speed in the field. In contrast to temazepam, we found that irbesartan exposure did not affect behaviour in the laboratory, field, or the relationship between the two end-points. However, irbesartan was also not readily taken up into fish tissue (i.e. below detection levels in the muscle tissue), while temazepam bioconcentrated (bioconcentration factor 7.68) rapidly (t(1/2) < 24 h). Our findings add to a growing literature showing that benzodiazepine pollutants can modulate fish behaviour and that laboratory assays may be less sensitive at detecting the effects of pollutants compared to measuring effects in natural settings. Therefore, we underscore the importance of measuring behavioural effects in the natural environment.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 207, p. 170-178
Keywords [en]
Ecotoxicology, Scototaxis, Steady-state, In situ, Bioconcentration
National Category
Oceanography, Hydrology and Water Resources Ecology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-162518DOI: 10.1016/j.aquatox.2018.11.028ISI: 000457659300019PubMedID: 30576864OAI: oai:DiVA.org:umu-162518DiVA, id: diva2:1344512
Available from: 2019-08-21 Created: 2019-08-21 Last updated: 2019-08-21Bibliographically approved

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McCallum, ErinSundelin, AnnaFick, JerkerKlaminder, JonatanBrodin, Tomas

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McCallum, ErinSundelin, AnnaFick, JerkerKlaminder, JonatanBrodin, Tomas
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Aquatic Toxicology
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