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Investigating tissue bioconcentration and the behavioural effects of two pharmaceutical pollutants on sea trout (Salmo trutta) in the laboratory and field
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap. Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.ORCID-id: 0000-0001-5426-9652
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.ORCID-id: 0000-0002-3949-7371
Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.
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2019 (Engelska)Ingår i: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 207, s. 170-178Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Pharmaceuticals entering aquatic ecosystems via wastewater effluents are of increasing concern for wild animals. Because some pharmaceuticals are designed to modulate human behaviour, measuring the impacts of exposure to pharmaceuticals on fish behaviour has become a valuable endpoint. While laboratory studies have shown that pharmaceuticals can affect fish behaviour, there is a lack of understanding if behaviour is similarly affected in natural environments. Here, we exposed sea trout (Salmo trutta) smolts to two concentrations of two pharmaceutical pollutants often detected in surface waters: temazepam (a benzodiazepine, anxiolytic) or irbesartan (an angiotensin II receptor blocker, anti-hypertensive). We tested the hypothesis that changes to behavioural traits (anxiety and activity) measured in laboratory trials following exposure are predictive of behaviour in the natural environment (downstream migration). Measures of anxiety and activity in the laboratory assay did not vary with temazepam treatment, but temazepam-exposed fish began migrating faster in the field. Activity in the laboratory assay did predict overall migration speed in the field. In contrast to temazepam, we found that irbesartan exposure did not affect behaviour in the laboratory, field, or the relationship between the two end-points. However, irbesartan was also not readily taken up into fish tissue (i.e. below detection levels in the muscle tissue), while temazepam bioconcentrated (bioconcentration factor 7.68) rapidly (t(1/2) < 24 h). Our findings add to a growing literature showing that benzodiazepine pollutants can modulate fish behaviour and that laboratory assays may be less sensitive at detecting the effects of pollutants compared to measuring effects in natural settings. Therefore, we underscore the importance of measuring behavioural effects in the natural environment.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 207, s. 170-178
Nyckelord [en]
Ecotoxicology, Scototaxis, Steady-state, In situ, Bioconcentration
Nationell ämneskategori
Oceanografi, hydrologi och vattenresurser Ekologi Farmakologi och toxikologi
Identifikatorer
URN: urn:nbn:se:umu:diva-162518DOI: 10.1016/j.aquatox.2018.11.028ISI: 000457659300019PubMedID: 30576864OAI: oai:DiVA.org:umu-162518DiVA, id: diva2:1344512
Tillgänglig från: 2019-08-21 Skapad: 2019-08-21 Senast uppdaterad: 2019-08-21Bibliografiskt granskad

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McCallum, ErinSundelin, AnnaFick, JerkerKlaminder, JonatanBrodin, Tomas

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McCallum, ErinSundelin, AnnaFick, JerkerKlaminder, JonatanBrodin, Tomas
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Institutionen för ekologi, miljö och geovetenskapKemiska institutionen
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Aquatic Toxicology
Oceanografi, hydrologi och vattenresurserEkologiFarmakologi och toxikologi

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