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Mutational and non mutational adaptation of Salmonella enterica to the gall bladder
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain.ORCID iD: 0000-0002-8349-360X
2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 5203Article in journal (Refereed) Published
Abstract [en]

During systemic infection of susceptible hosts, Salmonella enterica colonizes the gall bladder, which contains lethal concentrations of bile salts. Recovery of Salmonella cells from the gall bladder of infected mice yields two types of isolates: (i) bile-resistant mutants; (ii) isolates that survive lethal selection without mutation. Bile-resistant mutants are recovered at frequencies high enough to suggest that increased mutation rates may occur in the gall bladder, thus providing a tentative example of stress-induced mutation in a natural environment. However, most bile-resistant mutants characterized in this study show defects in traits that are relevant for Salmonella colonization of the animal host. Mutation may thus permit short-term adaptation to the gall bladder at the expense of losing fitness for transmission to new hosts. In contrast, non mutational adaptation may have evolved as a fitness-preserving strategy. Failure of RpoS(-) mutants to colonize the gall bladder supports the involvement of the general stress response in non mutational adaptation.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 5203
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-162493DOI: 10.1038/s41598-019-41600-8ISI: 000462298600090PubMedID: 30914708OAI: oai:DiVA.org:umu-162493DiVA, id: diva2:1344931
Available from: 2019-08-22 Created: 2019-08-22 Last updated: 2019-08-22Bibliographically approved

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Hernandez, Sara B.

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