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Significance and Translational Value of High-Frequency Cortico-Basal Ganglia Oscillations in Parkinson's Disease
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Department of Experimental Medical Science, The Group for Integrative Neurophysiology and Neurotechnology, Lund University, Lund, Sweden.ORCID iD: 0000-0001-6697-0171
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Department of Experimental Medical Science, The Group for Integrative Neurophysiology and Neurotechnology, Lund University, Lund, Sweden.
2019 (English)In: Journal of Parkinson's Disease, ISSN 1877-7171, E-ISSN 1877-718X, Vol. 9, no 1, p. 183-196Article in journal (Refereed) Published
Abstract [en]

The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states. We review the occurrence of different types of fast oscillations and the evidence supporting their pathophysiological role. We also provide a general discussion on the definition, possible mechanisms, and translational value of synchronized oscillations of different frequencies in cortico-basal ganglia structures. Revealing how oscillatory phenomena are caused and spread in cortico-basal ganglia-thalamocortical networks will offer a key to unlock the neural codes of both motor and non-motor symptoms in PD. In preclinical therapeutic research, recording of oscillatory neural activities holds the promise to unravel mechanisms of action of current and future treatments.

Place, publisher, year, edition, pages
IOS Press, 2019. Vol. 9, no 1, p. 183-196
Keywords [en]
Pathophysiology, movement disorders, bradykinesia, dyskinesia, animal models, cortex, thalamus
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-162779DOI: 10.3233/JPD-181480ISI: 000457741900015PubMedID: 30594935OAI: oai:DiVA.org:umu-162779DiVA, id: diva2:1348373
Available from: 2019-09-04 Created: 2019-09-04 Last updated: 2019-09-04Bibliographically approved

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Petersson, Per

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