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Preliminary exploration of hsa_circ_0032131 levels in peripheral blood as a potential diagnostic biomarker of osteoarthritis
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, People's Republic of China.
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
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2019 (English)In: Genetic Testing and Molecular Biomarkers, ISSN 1945-0265, E-ISSN 1945-0257, Vol. 23, no 10, p. 717-721, article id 31526191Article in journal (Refereed) Published
Abstract [en]

Background: Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by articular cartilage degeneration and synovitis. CircRNAs are increasingly being recognized as functional endogenous RNAs with a stable structure and high tissue specificity. Recent studies have shown that some circRNAs may be involved in the initiation and progression of OA and that there is differential expression of circRNAs in chondrocytes in vitro isolated from patients with OA.

Purposes: In this study, we aimed to determine if circRNA levels in the peripheral blood of Chinese Han patients with OA would be diagnostic based on the previous in vitro studies.

Methods: We collected peripheral blood samples from 25 patients suffering from OA and 25 healthy controls and measured hsa_circ_0032131_CBC1 RNA levels through quantitative RT-PCR (qRT-PCR). The statistical basis for evaluating the diagnostic value was to calculate the area under the receiver operator characteristic (ROC) curve.

Results: The results of the qRT-PCR for hsa_circ_0032131_CBC1 were consistent with those of the microarray analysis. The ROC curve shows that hsa_circ_0032131 holds diagnostic value for OA (0.8455, p < 0.01).

Conclusions: Our research indicates that differentially expressed circRNAs may be involved in the development of OA and could be used diagnostically.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2019. Vol. 23, no 10, p. 717-721, article id 31526191
Keywords [en]
circRNA, diagnostic biomarker, osteoarthritis, peripheral blood
National Category
Cell and Molecular Biology Rheumatology and Autoimmunity Orthopaedics Biomedical Laboratory Science/Technology
Research subject
Molecular Biology; Orthopaedics; rheumatology; Medical Biochemistry
Identifiers
URN: urn:nbn:se:umu:diva-163634DOI: 10.1089/gtmb.2019.0036ISI: 000486800600001PubMedID: 31526191OAI: oai:DiVA.org:umu-163634DiVA, id: diva2:1356146
Available from: 2019-10-01 Created: 2019-10-01 Last updated: 2019-10-22

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Lammi, Mikko

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Cell and Molecular BiologyRheumatology and AutoimmunityOrthopaedicsBiomedical Laboratory Science/Technology

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