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Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents.
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2019 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, article id S0261-5614(19)33028-6Article in journal (Refereed) In press
Abstract [en]

AIM: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.

METHODS: In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.

RESULTS: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.

CONCLUSION: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.

Place, publisher, year, edition, pages
2019. article id S0261-5614(19)33028-6
Keywords [en]
C-reactive protein, Inflammation, Interaction, Mediterranean diet, Nutrigenomics, Single nucleotide polymorphism
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Nursing
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URN: urn:nbn:se:umu:diva-164179DOI: 10.1016/j.clnu.2019.08.016PubMedID: 31500937Scopus ID: 2-s2.0-85071870278OAI: oai:DiVA.org:umu-164179DiVA, id: diva2:1361207
Available from: 2019-10-15 Created: 2019-10-15 Last updated: 2019-10-18

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Forsner, Maria

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