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Structure-function associations of successful associative encoding
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2019 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 201, article id 116020Article in journal (Refereed) Published
Abstract [en]

Functional magnetic resonance imaging (MRI) studies have demonstrated a critical role of hippocampus and inferior frontal gyrus (IFG) in associative memory. Similarly, evidence from structural MRI studies suggests a relationship between gray-matter volume in these regions and associative memory. However, how brain volume and activity relate to each other during associative-memory formation remains unclear. Here, we used joint independent component analysis (jICA) to examine how gray-matter volume and brain activity would be associated during associative encoding, especially in medial-temporal lobe (MTL) and IFG. T1-weighted images were collected from 27 young adults, and functional MRI was employed during intentional encoding of object pairs. A subsequent recognition task tested participants' memory performance. Unimodal analyses using voxel-based morphometry revealed that participants with better associative memory showed larger gray-matter volume in left anterior hippocampus. Results from the jICA revealed one component that comprised a covariance pattern between gray-matter volume in anterior and posterior MTL and encoding-related activity in IFG. Our findings suggest that gray matter within the MTL modulates distally distinct parts of the associative encoding circuit, and extend previous studies that demonstrated MTL-IFG functional connectivity during associative memory tasks.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 201, article id 116020
National Category
Radiology, Nuclear Medicine and Medical Imaging Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-164029DOI: 10.1016/j.neuroimage.2019.116020ISI: 000487755700027PubMedID: 31323259OAI: oai:DiVA.org:umu-164029DiVA, id: diva2:1361620
Available from: 2019-10-16 Created: 2019-10-16 Last updated: 2019-10-16Bibliographically approved

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Salami, Alireza

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Umeå Centre for Functional Brain Imaging (UFBI)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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NeuroImage
Radiology, Nuclear Medicine and Medical ImagingNeurosciences

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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  • de-DE
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