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Effects of combined training on risk factors for metabolic diseases and sex-specific difference in response: An explorative study
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Sports Medicine.
2019 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesisAlternative title
Effekter av kombinerad träning på riskfaktorer för metabola sjukdomar samt könsspecifika skillnader i respons: En explorativ studie : En explorativ studie (Swedish)
Abstract [en]

Obesity and physical inactivity, in combination and each per se, increase the risk of several metabolic diseases linked to chronic low-grade inflammation such as type 2 diabetes (T2D) and cardiovascular disease (CVD), cancer and dementia. Physical activity has been shown to promote beneficial physiological and molecular adaptions which can reduce the risk of metabolic disorders. The mechanisms behind these events are not yet fully understood. Additionally, studies investigating sex-specific differences in physiological and molecular adaptions to training in young obese females and males are lacking.

The present explorative intervention study investigates the effect of seven weeks combined resistance and conditioning training on a large set established risk factors and potential new risk factors of metabolic diseases. The secondary aim was to test sex-specific differences in effect in response to the training intervention. Eighteen overweight (median BMI 30.2 kg/m2), young (median 26.0 years) and healthy females and males with a sedentary lifestyle completed the study. The training intervention generated improvements in several factors related to body composition, physical capacity and metabolic function. Surprisingly, there were statistically significant increases in serum concentration of monocyte chemoattractant protein-1 (MCP-1), endothelial leukocyte adhesion molecule-1 (E-selectin), pentraxin 3 (PTX3), vascular cell adhesion protein (VCAM) and Chaperon S (Cath S), all associated to inflammatory conditions, which may indicate that these factors are involved in metabolic and physiologic processes beyond inflammation. These interesting findings give rise to further questions to address in future trials. While the pattern of change of many variables displayed disparities between females and males, only a few statistically significant sex-differences in effect were found.

Place, publisher, year, edition, pages
2019. , p. 49
Keywords [en]
inflammation, physical exercise, overweight, metabolic diseases, training, health
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:umu:diva-164224OAI: oai:DiVA.org:umu-164224DiVA, id: diva2:1361844
Educational program
Master program in Sports Medicine
Supervisors
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Projects
ProhealthAvailable from: 2019-12-10 Created: 2019-10-17 Last updated: 2019-12-10Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
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  • asciidoc
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