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The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
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2019 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 365, no 6455, article id eaaw2619Article in journal (Refereed) Published
Abstract [en]

Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2019. Vol. 365, no 6455, article id eaaw2619
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-163672DOI: 10.1126/science.aaw2619ISI: 000482464000044PubMedID: 31439762OAI: oai:DiVA.org:umu-163672DiVA, id: diva2:1362835
Available from: 2019-10-21 Created: 2019-10-21 Last updated: 2019-10-21Bibliographically approved

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Billker, Oliver

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Russell, Andrew J. C.Heaton, HaynesNatarajan, KedarVerzier, Lisa H.Rayner, Julian C.Billker, Oliver
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Molecular Infection Medicine Sweden (MIMS)Department of Molecular Biology (Faculty of Science and Technology)
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