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A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Sabourilab)
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2019 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773Article in journal (Refereed) Accepted
Abstract [en]

The design of turn‐on dyes with optical signals sensitive to the formation of supramolecular structures provides fascinating and underexplored opportunities for G‐quadruplex (G4) DNA detection and characterization. Here, we show a new switching mechanism that relies on the recognition‐driven disaggregation (on‐signal) of an ultrabright coumarin‐quinazoline conjugate. The synthesized probe selectively lights‐up parallel G4 DNA structures via the disassembly of its supramolecular state, demonstrating outputs that are easily integrable into a label free molecular logic system. Finally, our molecule preferentially stains the G4‐rich nucleoli of cancer cells.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2019.
National Category
Natural Sciences Medical and Health Sciences
Research subject
Medical Biochemistry
Identifiers
URN: urn:nbn:se:umu:diva-164662DOI: 10.1002/anie.201912027OAI: oai:DiVA.org:umu-164662DiVA, id: diva2:1365659
Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-10-28

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Deiana, MarcoChand, KaramJamroskovic, JanObi, IkennaChorell, ErikSabouri, Nasim

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Deiana, MarcoChand, KaramJamroskovic, JanObi, IkennaChorell, ErikSabouri, Nasim
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Department of Medical Biochemistry and BiophysicsDepartment of Chemistry
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Angewandte Chemie International Edition
Natural SciencesMedical and Health Sciences

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