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Bacterial genotoxin functions as immune-modulator and promotes host survival
Dept. of Cell and Molecular Biology, Karolinska Institute, Stockholm Sweden. (Teresa Frisan)ORCID iD: 0000-0002-1209-0942
2016 (English)In: Microbial cell (Graz, Austria), ISSN 2311-2638, Vol. 3, no 8, p. 355-357Article in journal (Refereed) Published
Abstract [en]

Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells. However, little is known about their function in vivo. Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative, intracellular bacterium that causes typhoid fever, a debilitating disease infecting more than 20 million people every year. S. Typhiproduce a genotoxin named typhoid toxin (TT), but its role in the contest of host infection is poorly characterized. The major obstacle in addressing this issue is that S. Typhi is exclusively a human pathogen. To overcome this limitation, we have used as model bacterium S. Typhimurium, and engineered it to produce endogenous levels of an active and inactive typhoid toxin, hereby named as TT (or genotoxic) and cdtB (or control), respectively. To our surprise, infection with the genotoxin strain strongly suppressed intestinal inflammation, leading to a better survival of the host during the acute phase of infection, suggesting typhoid toxin may exert a protective role. The presence of a functional genotoxin was also associated with an increased frequency of asymptomatic carriers.

Place, publisher, year, edition, pages
Shared Science Publishers , 2016. Vol. 3, no 8, p. 355-357
Keywords [en]
genotoxin, Salmonella, typhoid toxin, DNA damage, inflammation, persistent infection
National Category
Cell and Molecular Biology Infectious Medicine Microbiology Immunology
Identifiers
URN: urn:nbn:se:umu:diva-165071DOI: 10.15698/mic2016.08.520ISI: 000384679300005PubMedID: 28357372OAI: oai:DiVA.org:umu-165071DiVA, id: diva2:1368766
Available from: 2019-11-08 Created: 2019-11-08 Last updated: 2019-11-08Bibliographically approved

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Frisan, Teresa

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • de-DE
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  • en-US
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  • nn-NO
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Output format
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