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Bacterial genotoxins: the long journey to the nucleus of mammalian cells
Dept. Cell and Molecular Biology, Karolinska Institutet.ORCID iD: 0000-0002-1209-0942
2016 (English)In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1858, no 3, p. 567-575, article id S0005-2736(15)00267-9Article, review/survey (Refereed) Published
Abstract [en]

Bacterial protein genotoxins target the DNA of eukaryotic cells, causing DNA single and double strand breaks. The final outcome of the intoxication is induction of DNA damage responses and activation of DNA repair pathways. When the damage is beyond repair, the target cell either undergoes apoptosis or enters a permanent quiescent stage, known as cellular senescence. In certain instances, intoxicated cells can survive and proliferate. This event leads to accumulation of genomic instability and acquisition of malignant traits, underlining the carcinogenic potential of these toxins. The toxicity is dependent on the toxins' internalization and trafficking from the extracellular environment to the nucleus, and requires a complex interaction with several cellular membrane compartments: the plasma membrane, the endosomes, the trans Golgi network and the endoplasmic reticulum, and finally the nucleus. This review will discuss the current knowledge of the bacterial genotoxins internalization pathways and will highlight the issues that still remain unanswered. This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 1858, no 3, p. 567-575, article id S0005-2736(15)00267-9
Keywords [en]
Bacterial genotoxins, Cytolethal distending toxin, Endoplasmic reticulum, Intracellular trafficking, Lipid rafts, Nucleus, Retrograde transport, Toxin receptor, Trans Golgi network, Typhoid toxin
National Category
Cell and Molecular Biology Infectious Medicine Immunology Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-165074DOI: 10.1016/j.bbamem.2015.08.016ISI: 000370307700012PubMedID: 26299818OAI: oai:DiVA.org:umu-165074DiVA, id: diva2:1368838
Available from: 2019-11-08 Created: 2019-11-08 Last updated: 2019-11-08Bibliographically approved

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Frisan, Teresa

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