umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bacterial Genotoxins: Merging the DNA Damage Response into Infection Biology
Department Cell and Molecular Biology, Karolinska Institutet. (Teresa Frisan)ORCID iD: 0000-0002-1209-0942
2015 (English)In: Biomolecules, E-ISSN 2218-273X, Vol. 5, no 3, p. 1762-1782Article, review/survey (Refereed) Published
Abstract [en]

Bacterial genotoxins are unique among bacterial toxins as their molecular target is DNA. The consequence of intoxication or infection is induction of DNA breaks that, if not properly repaired, results in irreversible cell cycle arrest (senescence) or death of the target cells. At present, only three bacterial genotoxins have been identified. Two are protein toxins: the cytolethal distending toxin (CDT) family produced by a number of Gram-negative bacteria and the typhoid toxin produced by Salmonella enterica serovar Typhi. The third member, colibactin, is a peptide-polyketide genotoxin, produced by strains belonging to the phylogenetic group B2 of Escherichia coli. This review will present the cellular effects of acute and chronic intoxication or infection with the genotoxins-producing bacteria. The carcinogenic properties and the role of these effectors in the context of the host-microbe interaction will be discussed. We will further highlight the open questions that remain to be solved regarding the biology of this unusual family of bacterial toxins.

Place, publisher, year, edition, pages
MDPI, 2015. Vol. 5, no 3, p. 1762-1782
Keywords [en]
DNA damage response, bacterial genotoxins, cancer, chronic infection, probiotics
National Category
Cell and Molecular Biology Cancer and Oncology Infectious Medicine Immunology Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-165079DOI: 10.3390/biom5031762ISI: 000362504200028PubMedID: 26270677OAI: oai:DiVA.org:umu-165079DiVA, id: diva2:1368840
Available from: 2019-11-08 Created: 2019-11-08 Last updated: 2019-11-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Frisan, Teresa

Search in DiVA

By author/editor
Frisan, Teresa
In the same journal
Biomolecules
Cell and Molecular BiologyCancer and OncologyInfectious MedicineImmunologyMicrobiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf