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The biology of the cytolethal distending toxins
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. (Teresa Frisan)ORCID-id: 0000-0002-1209-0942
2011 (Engelska)Ingår i: Toxins, ISSN 2072-6651, E-ISSN 2072-6651, Vol. 3, nr 3, s. 172-190Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

The cytolethal distending toxins (CDTs), produced by a variety of Gram-negative pathogenic bacteria, are the first bacterial genotoxins described, since they cause DNA damage in the target cells. CDT is an A-B(2) toxin, where the CdtA and CdtC subunits are required to mediate the binding on the surface of the target cells, allowing internalization of the active CdtB subunit, which is functionally homologous to the mammalian deoxyribonuclease I. The nature of the surface receptor is still poorly characterized, however binding of CDT requires intact lipid rafts, and its internalization occurs via dynamin-dependent endocytosis. The toxin is retrograde transported through the Golgi complex and the endoplasmic reticulum, and subsequently translocated into the nuclear compartment, where it exerts the toxic activity. Cellular intoxication induces DNA damage and activation of the DNA damage responses, which results in arrest of the target cells in the G1 and/or G2 phases of the cell cycle and activation of DNA repair mechanisms. Cells that fail to repair the damage will senesce or undergo apoptosis. This review will focus on the well-characterized aspects of the CDT biology and discuss the questions that still remain unanswered.

Ort, förlag, år, upplaga, sidor
MDPI, 2011. Vol. 3, nr 3, s. 172-190
Nyckelord [en]
DNA damage, DNA damage response, bacterial genotoxin, chancroid, colitis/hepatitis, cytolethal distending toxin, periodontitis, survival signals, toxin internalization, virulence factor
Nationell ämneskategori
Cell- och molekylärbiologi Cellbiologi Immunologi Mikrobiologi Genetik
Identifikatorer
URN: urn:nbn:se:umu:diva-165143DOI: 10.3390/toxins3030172ISI: 000307975400002PubMedID: 22069704OAI: oai:DiVA.org:umu-165143DiVA, id: diva2:1369410
Tillgänglig från: 2019-11-12 Skapad: 2019-11-12 Senast uppdaterad: 2019-11-12Bibliografiskt granskad

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