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Common brain disorders are associated with heritable patterns of apparent aging of the brain
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2019 (English)In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 22, no 10, p. 1617-+Article in journal (Refereed) Published
Abstract [en]

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 22, no 10, p. 1617-+
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Neurosciences
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URN: urn:nbn:se:umu:diva-165360DOI: 10.1038/s41593-019-0471-7ISI: 000493396200012PubMedID: 31551603OAI: oai:DiVA.org:umu-165360DiVA, id: diva2:1372119
Available from: 2019-11-22 Created: 2019-11-22 Last updated: 2019-11-22Bibliographically approved

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Nyberg, Lars

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Kaufmann, Tobiasvan der Meer, DennisBorgwardt, StefanFranke, BarbaraJonsson, Erik G.Nyberg, LarsWestman, EricZiegler, Georg C.Westlye, Lars T.
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Department of Radiation SciencesDepartment of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)
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