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The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
Umeå University, Faculty of Medicine, Department of Medical Biosciences. International Centre for Cancer Vaccine Science (ICCVS), University of Gdansk, Gdansk, Poland; Université Paris 7, INSERM, UMR 1162, Paris, France; Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czechia.
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2019 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, article id 2388Article, review/survey (Refereed) Published
Abstract [en]

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, article id 2388
Keywords [en]
toll-like receptors, immuno-oncology, anti-cancer immunity, tumor rejection, immunotherapy
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-165354DOI: 10.3389/fimmu.2019.02388ISI: 000494664000001PubMedID: 31695691OAI: oai:DiVA.org:umu-165354DiVA, id: diva2:1372641
Funder
NIH (National Institute of Health), 1R01AI123820-01Available from: 2019-11-25 Created: 2019-11-25 Last updated: 2019-11-25Bibliographically approved

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Fåhraeus, Robin

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