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Association of metabolic syndrome with cognitive decline in Western populations: A literature review
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health.
2018 (English)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Introduction: With increasing ageing population in the recent world and caring cost for cognitively impaired people, there is a unique need to better understand the preventable risk factors and their influence on cognition as well. One prevalent and modifiable risk factor is metabolic syndrome, a cluster of cardiovascular risk factors. The recognition of metabolic syndrome as a major risk factor for various diseases has come into focus in recent years. We see some recent and previous reviews examine association between MS and cognitive decline globally rather than certain geographical context. In our review we made it narrow to western populations (North America and Europe) due to same context, culture and lifestyle.

Objective: The aim of this study was to examine the association between MS and cognitive decline in Western populations.

Method: On 15th April 2018 articles search were performed in PubMed for studies which examine association between MS and cognitive decline. MS has to be diagnosed based on the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) and cognitive decline as diagnosed patient of dementia, AD (Alzheimer’s disease), VaD (Vascular dementia), mild cognitive impairment (MCI) or neuropsychiatric test for at least one cognitive domain.

Result: After search and screen by our exclusion and inclusion criteria we have selected total ten studies. Role of MS for cognitive decline showed heterogeneous results. Some studies showing positive association between MS and cognitive decline and some are showing mixed association. As our findings from selected studies are discrepant, we have investigated the association of individual component of MS and other covariate’s with cognition. Hyperglycemia, HTN and Inflammatory marker, play an important role in this association.

Discussion: Our all studies were longitudinal follow up studies except one which was cross sectional. There is lack of consensus on the relationship of MS with cognitive decline in our included studies as well as in previous reviews. Changes in cognition of MS patient specially in global function, memory and executive performance was significant in association and hyper glycaemia consistently associated with cognitive decline.

Conclusion: Our included studies in the reviews cannot show us explicit relationship between MS and cognitive decline. Further larger and higher quality studies in this field are still needed.

Place, publisher, year, edition, pages
2018. , p. 22
Series
Centre for Public Health Report Series, ISSN 1651-341X ; 2018:57
Keywords [en]
Metabolic syndrome (MS), cognitive decline, Western populations
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-165558OAI: oai:DiVA.org:umu-165558DiVA, id: diva2:1373220
Educational program
Master's Programme in Public Health
Presentation
2018-10-18, Butajira, Building 5B, NUS, Department of Epidemiology and Global Health, 3rd floor, Umeå University, Umeå, 13:00 (English)
Supervisors
Examiners
Available from: 2019-11-27 Created: 2019-11-26 Last updated: 2019-11-27Bibliographically approved

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Khandaker, Nur Uddin
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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
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Language
  • de-DE
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  • en-US
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  • nn-NO
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More languages
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