umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tübingen ,Stuttgart , Germany.ORCID iD: 0000-0002-6716-8284
Show others and affiliations
2009 (English)In: Mucosal Immunology, ISSN 1933-0219, E-ISSN 1935-3456, Vol. 2, no 2, p. 166-172Article in journal (Refereed) Published
Abstract [en]

Inducible epithelial human beta-defensins (hBD) play an important role in intestinal barrier function. In vitro studies showed that clinically effective probiotics induce antimicrobial hBD-2. Here, we aimed to assess the in vivo effect in healthy volunteers and also addressed how defensins affect probiotic survival. Symbioflor 2 containing one strain of several viable genotypes of Escherichia coli was administered to 23 healthy individuals. After 3 weeks, fecal hBD-2 peptide was increased in 78% (mean 3.7-fold; P<0.0001). Interestingly, the fecal hBD-2 peptide was still elevated 9 weeks after treatment (P=0.008). In vitro studies revealed that this effect was mediated by only one out of three tested E. coli genotypes and comparable to probiotic E. coli Nissle 1917 (10- to 15-fold). Functional assays showed that all tested bacteria were similarly killed by defensins allowing to speculate about a suicidal character of this effect. Defensin induction seems to be a common and important mechanism of probiotic treatment.

Place, publisher, year, edition, pages
Nature Publishing Group, 2009. Vol. 2, no 2, p. 166-172
National Category
Immunology Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-166030DOI: 10.1038/mi.2008.77ISI: 000263327800008PubMedID: 19129752OAI: oai:DiVA.org:umu-166030DiVA, id: diva2:1376353
Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2019-12-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Schröder, Björn

Search in DiVA

By author/editor
Schröder, Björn
In the same journal
Mucosal Immunology
ImmunologyGastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 5 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf