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Human beta-defensin 1: from defence to offence
2012 (German)In: Zeitschrift für Gastroenterologie - German Journal of Gastroenterology, ISSN 0044-2771, E-ISSN 1439-7803, Vol. 50, no 11, p. 1171-5Article in journal (Refereed) Published
Abstract [de]

The human gut is colonised by about one kilogram of commensal bacteria. These microorganisms are a potential threat, thus an efficient defence system is crucial in preventing bacterial translocation and infection. Besides other mechanisms of protection humans produce antimicrobial peptides (AMPs) that are able to kill a broad range of microorganisms. The human beta-defensin 1 (hBD-1) plays a major role because it is produced constitutively by all human epithelia and some immune cells. In contrast to other AMPs, however, the biological function of hBD-1 has remained unclear since the antibiotic activity of hBD-1 in vitro was only marginal. But still, several diseases have been associated with genetic polymorphisms in the hBD-1 encoding gene. Herein we discuss why the biological role of hBD-1 has been overlooked and how hBD-1 can be activated by chemical reduction. We elaborate on the biological significance of this activation and its importance for inflammatory bowel disease.

Place, publisher, year, edition, pages
2012. Vol. 50, no 11, p. 1171-5
National Category
Immunology Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-166026DOI: 10.1055/s-0032-1312865PubMedID: 23150110OAI: oai:DiVA.org:umu-166026DiVA, id: diva2:1377904
Available from: 2019-12-12 Created: 2019-12-12 Last updated: 2019-12-13Bibliographically approved

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Schröder, Björn

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