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Plasmodium berghei: infectivity of mice to Anopheles stephensi mosquitoes
Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road,London, United Kingdom.ORCID iD: 0000-0003-1716-168x
1996 (English)In: Experimental parasitology, ISSN 0014-4894, E-ISSN 1090-2449, Vol. 84, no 3, p. 371-379Article in journal (Refereed) Published
Abstract [en]

The infectivity of P. berghei-infected TO mice to mosquitoes declines rapidly 2 to 5 days after blood inoculation, in spite of rising numbers of gametocytes in the blood. This pattern is typical of many malaria infections and various factors, particularly specific and nonspecific immune responses, have previously been implicated in the decline. Here we report that (1) simple physiological changes in the mouse blood, namely, falling pH and bicarbonate levels induced by high parasitaemias, are responsible for the sustained inhibition of infectivity; (2) the inhibition is reversible in vivo by the addition of sodium bicarbonate alone; (3) the inhibition occurs at the point of exflagellation; (4) contrary to previous observations (Kawamoto et al. 1992), exflagellation in P. berghei, like that in P. gallinaceum (Bishop and McConnachie 1956; Nijhout and Carter 1978; Nijhout 1979) and P. falciparum (Ogwan'g et al. 1993), is dependent on extracellular bicarbonate; and (5) induction of exflagellation by a mosquito factor is bicarbonate dependent. These new observations are critical to the design and interpretation of experiments on other transmission blocking phenomena.

Place, publisher, year, edition, pages
1996. Vol. 84, no 3, p. 371-379
Keywords [en]
Animals, Anopheles/*parasitology, Bicarbonates/blood/pharmacology, Buffers, Hydrogen-Ion Concentration, Insect Vectors/*parasitology, Kinetics, Malaria/parasitology/*transmission, Mice, Parasitemia/parasitology, Plasmodium berghei/drug effects/*physiology
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-165903DOI: 10.1006/expr.1996.0125ISI: A1996VW08100007PubMedID: 8948326OAI: oai:DiVA.org:umu-165903DiVA, id: diva2:1379295
Conference
United States
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-19Bibliographically approved

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Billker, Oliver

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