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Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut
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2004 (English)In: Experimental parasitology, ISSN 0014-4894, E-ISSN 1090-2449, Vol. 106, no 1-2, p. 30-36Article in journal (Refereed) Published
Abstract [en]

We studied the transmission-blocking effect of isonicotinic acid hydrazide (INH), a widely used anti-tuberculosis drug, against Plasmodium gallinaceum and Plasmodium berghei. INH-treatment of infected animals did not inhibit parasite development in the blood of the vertebrate host, but did inhibit exflagellation, ookinete formation, and oocyst development in the mosquito. Oocyst development was inhibited in a dose-dependent manner. The ED(50) in the P. gallinaceum/chicken/Aedes aegypti model and P. berghei/mouse/Anopheles stephensi model was 72 and 109 mg/kg, respectively. In marked contrast, in vitro exflagellation and ookinete development were not directly affected by physiological concentrations of INH. We suggest that INH exerts its inhibitory effects on the mosquito stages of the malaria parasite by an indirect, and at present undefined mechanism. Further elucidation of the mechanism how INH inhibits parasite development specifically on mosquito stages may allow us to identify new targets for malaria control strategy.

Place, publisher, year, edition, pages
2004. Vol. 106, no 1-2, p. 30-36
Keywords [en]
Aedes/*parasitology, Animals, Antimalarials/pharmacology, Antitubercular Agents/pharmacology, Chickens, Dose-Response Relationship, Drug, Female, Insect Vectors/*parasitology, Isoniazid/*pharmacology, Malaria/*prevention & control/transmission, Mice, Parasitemia/parasitology/prevention & control, Plasmodium berghei/*drug effects/growth & development/physiology, Plasmodium gallinaceum/*drug effects/growth & development/physiology
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Basic Medicine Cell and Molecular Biology
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URN: urn:nbn:se:umu:diva-165892DOI: 10.1016/j.exppara.2004.01.002PubMedID: 15013786OAI: oai:DiVA.org:umu-165892DiVA, id: diva2:1379341
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United States
Available from: 2019-12-17 Created: 2019-12-17 Last updated: 2019-12-17Bibliographically approved

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Billker, Oliver

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