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Evaluation of urine dipsticks for quality control of residual erythrocytes and leukocytes in leukocyte-depleted donor plasma
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry. Department of Clinical Chemistry and Transfusion Medicine, Växjö Central Hospital, Växjö.ORCID iD: 0000-0003-2844-1310
2019 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686Article in journal (Refereed) Epub ahead of print
Abstract [en]

Currently used methodologies for quality control of residual leukocytes and erythrocytes in leukocyte-depleted plasma are either expensive or time-consuming. It has been proposed that urine dipsticks could be used as a screening method for residual erythrocytes. The aim was, therefore, to evaluate if urine dipsticks could be used to detect residual erythrocytes and also residual leukocytes in leukocyte-depleted plasma. Dilution series ranging over the decision limits for residual erythrocytes and leukocytes were prepared. Positive, negative and overall agreements, as well as the precision and joint frequency distributions, were calculated for five dipstick analyzers and their corresponding dipsticks. Twenty-four consecutive leukocyte-depleted donor plasma samples were also tested. None of the dipstick analyzers had both a high positive and a high negative agreement. Accordingly, none of the analyzers were able to discriminate between cell concentrations close to the decision limits. The inconsistency count revealed differences in precision between the dipstick analyzers. In the 24 consecutive donor samples, no significant correlation between the dipstick analyzers and the reference methods were found. In conclusion, urine dipsticks are not suitable for quality control of residual leukocytes and erythrocytes in leukocyte-depleted donor plasma.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2019.
Keywords [en]
Quality control, transfusion, red blood cell, point-of-care testing, plasma, practice guideline
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:umu:diva-166509DOI: 10.1080/00365513.2019.1692233ISI: 000498464300001PubMedID: 31766902OAI: oai:DiVA.org:umu-166509DiVA, id: diva2:1380092
Available from: 2019-12-18 Created: 2019-12-18 Last updated: 2019-12-18

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Ekblom, Kim

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CiteExportLink to record
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  • apa
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