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Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Umeå University, Faculty of Medicine, Department of Medical Biosciences. Inserm, Paris, France; International Centre for Cancer Vaccine Science (ICCVS), University of Gdansk, Science, Gdansk, Poland; RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
2019 (English)In: Trends in Cell Biolology, ISSN 0962-8924, E-ISSN 1879-3088, Vol. 29, no 12, p. 929-939Article, review/survey (Refereed) Published
Abstract [en]

MHC class I presentation of short peptides enables CD8(+) T cell (TCD8+) immunosurveillance of tumors and intracellular pathogens. A key feature of the class I pathway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high selectivity of the access of protease-generated peptides to class I molecules. Similarly, in professional antigen-presenting cells, peptides from minute amounts of proteins introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides. Here, we propose that antigen processing is based on substrate channeling and review recent studies from the antigen processing and cell biology fields that provide a starting point for testing this hypothesis.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 29, no 12, p. 929-939
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-166381DOI: 10.1016/j.tcb.2019.09.004ISI: 000497668700001PubMedID: 31662235OAI: oai:DiVA.org:umu-166381DiVA, id: diva2:1380329
Available from: 2019-12-18 Created: 2019-12-18 Last updated: 2019-12-18Bibliographically approved

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Fåhraeus, Robin

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