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Thermic and tremorogenic effects of thyroliberin (TRH) in reserpine-treated mice--the non-involvement of GABA-ergic mechanisms.
Psychiatric Research Center, Ulleråker Hospital, University of Uppsala, S‐750 17 Uppsala, Sweden.
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1981 (English)In: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 33, no 9, p. 580-585Article in journal (Refereed) Published
Abstract [en]

Administration of thyroliberin (TRH) to reserpinized mice causes tremor and counteracts the hypothermia in a dose-dependent fashion. The thyroliberin response is inhibited by gamma-hydroxybutyric acid (GHB) and baclofen, but not by other, more specific GABA-ergic agents, such as THIP, gamma-acetylenic GABA, and sodium valproate. Picrotoxin neither potentiates nor inhibits the thyroliberin actions. Nor are the thyroliberin effects dependent on cholinergic, monoaminergic or histaminergic mechanisms. The results repudiate a current hypothesis, that the peptide actions may be mediated by GABA-ergic pathways in the brain.

Place, publisher, year, edition, pages
1981. Vol. 33, no 9, p. 580-585
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Physiology
Identifiers
URN: urn:nbn:se:umu:diva-167511DOI: 10.1111/j.2042-7158.1981.tb13870.xISI: A1981MF61600006PubMedID: 6117636OAI: oai:DiVA.org:umu-167511DiVA, id: diva2:1388052
Available from: 2020-01-23 Created: 2020-01-23 Last updated: 2020-01-23Bibliographically approved

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Koskinen, Lars-Owe D.

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