umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The effect of the calcium antagonist nimodipine on the detoxification of soman in anaesthetized rabbits.
Defence Research Establishment, Division of NBC Defence, 5‐907 82 Umeå, Sweden.
Defence Research Establishment, Division of NBC Defence, 5‐907 82 Umeå, Sweden.
Department of Neurosurgery, University Hospital of Umeå, S‐901 85 Umeå, Sweden.
1997 (English)In: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 49, no 3, p. 296-300Article in journal (Refereed) Published
Abstract [en]

The effect of nimodipine, a vasoactive calcium antagonist, on the disappearance of soman from blood was studied in anaesthetized rabbits intoxicated with soman (10.8 micrograms kg-1 i.v.). Blood samples from the left heart ventricle and femoral artery were used to investigate soman detoxification. The concentrations of the soman isomers C+P- and C-P- in blood samples were determined by gas chromatography coupled with high-resolution mass spectrometry. During the sampling, 15-300 s after soman injection, the soman concentration in control animals decreased from 50 to 0.029 ng mL-1; in animals pre-treated with nimodipine (10 mg kg-1) it decreased from 15 to 0.033 ng mL-1. In animals pre-treated with nimodipine the soman concentration was significantly reduced during the first minute of sampling. No differences were detected between soman concentrations in samples from the heart and femoral artery. Acetylcholinesterase inhibition was also used as an indicator of soman activity; there was no difference between the activity of this enzyme in different peripheral organs of control and nimodipine-treated animals. Nimodipine reduces the initial concentration of soman in the blood, which might be of significance in the treatment of soman intoxication.

Place, publisher, year, edition, pages
1997. Vol. 49, no 3, p. 296-300
National Category
Physiology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-167533DOI: 10.1111/j.2042-7158.1997.tb06799.xISI: A1997WR27400014PubMedID: 9231349OAI: oai:DiVA.org:umu-167533DiVA, id: diva2:1388093
Available from: 2020-01-23 Created: 2020-01-23 Last updated: 2020-01-24Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Koskinen, Lars-Owe D.

Search in DiVA

By author/editor
Koskinen, Lars-Owe D.
In the same journal
Journal of Pharmacy and Pharmacology (JPP)
PhysiologyPharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf