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White matter hyperintensities increases with traumatic brain injury severity: associations to neuropsychological performance and fatigue
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine. Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.ORCID iD: 0000-0003-2924-508x
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health. School of Sport Sciences, The Arctic University of Norway, Tromsø, Norway..ORCID iD: 0000-0003-3534-456x
2020 (English)In: Brain Injury, ISSN 0269-9052, E-ISSN 1362-301X, Vol. 34, no 3, p. 415-420Article in journal (Refereed) Published
Abstract [en]

Objective: To examine the prevalence of white matter hyperintensities (WMHs) in patients with traumatic brain injury (TBI) as compared to healthy controls, and to investigate whether there is an association between WMH lesion burden and performance on neuropsychological tests in patients with TBI.

Methods: A total of 59 patients with TBI and 27 age- and gender-matched healthy controls underwent thorough neuropsychological testing and magnetic resonance imaging. The quantification of WMH lesions was performed using the fully automated Lesion Segmentation Tool.

Results: WMH lesions were more common in patients with TBI than in healthy controls (p = .032), and increased with higher TBI severity (p = .025). Linear regressions showed that WMH lesions in patients with TBI were not related to performance on any neuropsychological tests (p > .05 for all). However, a negative relationship between number of WMH lesions in patients with TBI and self-assessed fatigue was found (r = - 0.33, p = .026).

Conclusion: WMH lesions are more common in patients with TBI than in healthy controls, and WMH lesions burden increases with TBI severity. These lesions could not explain decreased cognitive functioning in patients with TBI but did relate to decreased self-assessment of fatigue after TBI.

Place, publisher, year, edition, pages
Taylor & Francis, 2020. Vol. 34, no 3, p. 415-420
Keywords [en]
Traumatic Brain Injury, fatigue, magnetic Resonance Imaging, neuropsychology, white matter hyperintensities
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-168252DOI: 10.1080/02699052.2020.1725124ISI: 000513366800001PubMedID: 32037894OAI: oai:DiVA.org:umu-168252DiVA, id: diva2:1394063
Available from: 2020-02-18 Created: 2020-02-18 Last updated: 2020-03-13Bibliographically approved

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Berginström, NilsNordström, PeterNyberg, LarsNordström, Anna

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Berginström, NilsNordström, PeterNyberg, LarsNordström, Anna
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Geriatric MedicineDepartment of PsychologyDepartment of Radiation SciencesDepartment of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Section of Sustainable Health
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Brain Injury
Radiology, Nuclear Medicine and Medical Imaging

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