Evolution of subspecies of Francisella tularensis
2005 (English)In: Journal of Bacteriology, ISSN 0021-9193, E-ISSN 1098-5530, Vol. 187, no 11, 3903-3908 p.Article in journal (Refereed) Published
Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.
Place, publisher, year, edition, pages
2005. Vol. 187, no 11, 3903-3908 p.
Evolution; Molecular, Francisella tularensis/classification/*genetics/pathogenicity, Gene Deletion, Genome; Bacterial, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Phylogeny, Virulence
IdentifiersURN: urn:nbn:se:umu:diva-2382DOI: 10.1128/JB.187.11.3903-3908.2005PubMedID: 15901721OAI: oai:DiVA.org:umu-2382DiVA: diva2:140348