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Effects of low-load repetitive work and mental load on sensitising substances and metabolism in the trapezius muscle
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Sports Medicine.
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Low-load repetitive work (LLRW) and mental load are important risk factors for the development of workrelated muscle pain. The link between these risk factors and the development of pain is still not understood, but stimulation of chemo-sensitive receptors in the muscle probably plays an important role. It has been suggested that sensitising substances may accumulate in the muscle during LLRW, especially when combined with mental load.

The overall purpose of this thesis was to try to shed some light on the effects of LLRW on the concentration of sensitising substances (glutamate, prostaglandin E2 (PGE2), norepinephrine (NE)) and on metabolism (lactate, pyruvate and oxygenation) in the trapezius muscle of healthy controls (CON) and subjects with trapezius myalgia (TM).

A first step was to investigate whether females with TM exhibit higher absolute concentrations of glutamate and PGE2 in the affected muscle during rest. Using Microdialysis (MD) females with TM and asymptomatic controls were studied during four hours of rest. [Glutamate] and [PGE2] during rest did not differ between groups.

A second step was to investigate, in a simulated occupational setting, the effects of LLRW on the concentration of sensitising substances and metabolism in the trapezius muscle of TM and CON, and whether increased work duration resulted in a progressive effect. Asymptomatic females were studied during baseline rest, 30 versus 60 min work and recovery, using MD and near infrared spectroscopy (NIRS). Subjects with TM were studied during baseline rest, 30 min work and recovery. [Glutamate] and [lactate] increased in response to work, but not progressively with increased work duration. [Glutamate] was at all time points significantly lower in TM. [PGE2]and oxygenation remained unchanged during work for CON, while for TM oxygenation decreased significantly during work. In TM [pyruvate] increased during both work and recovery, and a significant interaction between groups was found for [pyruvate] during recovery; while moderately increased in CON it increased progressively in TM.

The effects of LLRW with and without superimposed mental load on intramuscular [NE], muscle activity and oxygen saturation in the trapezius were also investigated and compared. Using MD, electromyography and NIRS, healthy females were studied on two occasions; during 30 min LLRW and during 30 min LLRW with superimposed mental load. During work [NE], and muscle activity, were increased, while oxygenation decreased, but no differences between occasions. However, recovery of [NE] to baseline was slower after LLRW with superimposed mental load. The findings of the present thesis suggest: (i) no inflammation, or increased interstitial [glutamate] in TM; (ii) LLRW causes an increased anaerobic metabolism in both TM and CON; (iii) no effect of work duration was found; (iv) a significant difference in the effects of LLRW on the interstitial milieu of the trapezius muscle in TM as compared to CON; (v) LLRW causes a significant increase in [NE], but superimposed mental load does not cause a further increase; (vi) LLRW with a superimposed mental load may result in a slower recovery to baseline [NE] as compared with LLRW alone.

Place, publisher, year, edition, pages
Umeå: Idrottsmedicin , 2007.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1130
Keyword [en]
work-related muscle pain, microdialysis, near-infrared spectroscopy, electromyography, glutamate, lactate, pyruvate, prostaglandin E2, norepinephrine
Research subject
Occupational and Environmental Medicine
Identifiers
URN: urn:nbn:se:umu:diva-1393ISBN: 978-91-7264-424-3 (print)OAI: oai:DiVA.org:umu-1393DiVA: diva2:140866
Public defence
2007-11-02, sal 933, Norrlands universitetssjukhus, Umeå, 09:00 (English)
Opponent
Available from: 2007-10-17 Created: 2007-10-17 Last updated: 2009-10-07Bibliographically approved
List of papers
1. Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis.
Open this publication in new window or tab >>Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis.
Show others...
2005 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 5, 511-515 p.Article in journal (Refereed) Published
Keyword
Adult, Chronic Disease, Dinoprostone/*metabolism, Extracellular Fluid/chemistry/metabolism, Female, Fibromyalgia/*metabolism/physiopathology, Glutamic Acid/*metabolism, Homeostasis/physiology, Humans, Microdialysis, Middle Aged, Muscle; Skeletal/chemistry/*metabolism/physiopathology, Neck Pain/etiology/*metabolism/physiopathology, Shoulder Pain/etiology/*metabolism/physiopathology, Time Factors
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-16998 (URN)10.1016/j.ejpain.2004.11.004 (DOI)16139179 (PubMedID)
Available from: 2007-10-25 Created: 2007-10-25 Last updated: 2017-12-14Bibliographically approved
2. Effects of 30 versus 60 minutes of low-load work on intramuscular lactate, pyruvate, glutamate, prostaglandin E2 and oxygenation in the trapezius muscle of healthy females
Open this publication in new window or tab >>Effects of 30 versus 60 minutes of low-load work on intramuscular lactate, pyruvate, glutamate, prostaglandin E2 and oxygenation in the trapezius muscle of healthy females
2006 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 97, no 5, 557-565 p.Article in journal (Refereed) Published
Keyword
Adult, Dinoprostone/*metabolism, Exertion/*physiology, Female, Glutamic Acid/*metabolism, Humans, Lactates/blood/*metabolism, Microdialysis/methods, Middle Aged, Muscle Contraction/physiology, Muscle; Skeletal/*metabolism, Pyruvates/*metabolism, Spectroscopy; Near-Infrared, Time Factors, Weight Lifting/physiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-2639 (URN)10.1007/s00421-006-0216-7 (DOI)16767442 (PubMedID)
Available from: 2007-10-17 Created: 2007-10-17 Last updated: 2017-12-14Bibliographically approved
3. Effects of low-load work on sensitising substances and muscle metabolism in trapezius myalgia: determined with microdialysis and near infrared spectroscopy
Open this publication in new window or tab >>Effects of low-load work on sensitising substances and muscle metabolism in trapezius myalgia: determined with microdialysis and near infrared spectroscopy
(English)Article in journal (Refereed) Submitted
Identifiers
urn:nbn:se:umu:diva-2640 (URN)
Available from: 2007-10-17 Created: 2007-10-17Bibliographically approved
4. Changes in interstitial noradrenaline, trapezius muscle activity and oxygen saturation during low-load work and recovery
Open this publication in new window or tab >>Changes in interstitial noradrenaline, trapezius muscle activity and oxygen saturation during low-load work and recovery
2009 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 107, no 1, 31-42 p.Article in journal (Refereed) Published
Abstract [en]

Both physical as well as mental demands result in an increased activity in the sympathetic nervous system (SNS) with changes in blood-pressure and heart-rate. Through local release of catecholamines, e.g. noradrenaline (NAd) SNS exerts various actions at the muscle level. The aims of this study were to investigate the effects of low-load repetitive work alone and in combination with mental demands on local muscle interstitial noradrenaline concentration [NAd]i, muscle activity and oxygenation, assessed with microdialysis, surface electromyography, and near-infrared spectroscopy, respectively. Healthy females (n = 15) were exposed to (1) 30 min repetitive work (RW) and (2) 30 min repetitive work with superimposed mental load (RWML) on two different occasions. Muscle [NAd]i and muscle activity increased significantly in response to RW, but did not increase further during RWML. For RW, [NAd]i was found to be inversely correlated to muscle activity. Oxygenation decreased significantly during work, independently of occasion. Our findings indicate that low-load work causes significantly increased trapezius muscle [NAd]i in healthy females, and short periods of superimposed mental load do not add to this increase and further, that both muscle activity and oxygenation were unaffected by the superimposed mental load.

Keyword
Microdialysis, Near-infrared spectroscopy, Electromyography, Mental load, Subjective ratings, Healthy females
National Category
Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:umu:diva-2641 (URN)10.1007/s00421-009-1095-5 (DOI)
Available from: 2007-10-17 Created: 2007-10-17 Last updated: 2017-12-14Bibliographically approved

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