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Mortality and morbidity in lead smelter workers with concomitant exposure to arsenic
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Arsenic is a well-known lung carcinogen in humans. In 2006, IARC upgraded inorganic lead as a possible human carcinogen (2A). The aim of this thesis has been to evaluate the lung cancer mortality and incidence in long-term exposed primary lead smelter workers and also to estimate present exposures to arsenic and lead in relation to those occurring in the past. The basic cohort (N=3832 workers; hired before 1967 and followed up from 1950-1981; SMR comparisons with general and local reference populations) showed an excess of deaths for total mortality, malignant neoplasms (e.g. lung and stomach cancer), ischaemic heart diseases, and cerebrovascular diseases compared to the general population. In a subcohort of lead workers (N=437; regular blood lead sampling since 1950) only the raised SMR for lung cancer (162) was sustained. In a follow-up study of the basic cohort (N=3979), a subcohort of lead exposed workers (N=1992) was formed. The expected mortality in 1955-1987 and cancer incidence in 1958-1987 were calculated relative to county rates. A cumulative blood lead index (CBLI) was used for dose-response analyses. The lung cancer incidence was raised in the total cohort (SIR 2.8; 95 % CI 2.1 3.8). A higher lung cancer risk was observed in workers hired before 1950 (SIR 3.6; 95 % CI 2.6-5.0). The increased lung cancer risks were further elevated in the subcohort of lead exposed workers, especially in the highest exposed subgroup (SIR 5.1; 95 % 2.0-10.5; latency period of 15 y). No excesses of other malignancies were observed. The increased relative risks for lung cancer may have been caused by interactions between inorganic lead and other substances at the smelter, e.g. arsenic. To further analyze the effects from inorganic lead, two subcohorts of workers at the lead departments were formed from the original cohort (N=3979), one of 710 workers and the other of 383 workers. The lung cancer incidence was raised in both subcohorts (Lead subcohort 1; SIR 2.4; 95 % CI 1.2-4.5; Lead subcohort 2; SIR 3.6; 95 % CI 1.2-8.3). Among the 10 workers that had developed lung cancer in lead subcohort 1 all but one had a considerable exposure also to arsenic. Thus, a possible interaction effect between lead and arsenic may explain the increased lung cancer risks.

To further elucidate the impact from lead and arsenic a case control study was undertaken. In the basic cohort (N=3979), 46 male workers had contracted respiratory malignancies. They were compared with 141 agematched male referents from the primary smelter by conditional logistic regression analysis using smoking habits, cumulative blood lead and air arsenic exposure as predictor variables. The lung cancer cases showed a significantly higher smoking rate than referents (Odds ratio, OR = 4.0; 95 % CI 1.6-10.1; p=0.003). When restricted to smokers, the cumulative arsenic air exposure index, but not the lead exposure indices, were significantly higher among the cases (OR=1.07; 95 % CI 1.02-1.11; p = 0.005). Accordingly, cumulative arsenic exposure and smoking were identified as significant risk factors for the development of lung cancer in the final analyses, while lead exposure was not a significant risk factor. However, inorganic lead still may play a minor role in the multifactorial genesis of lung cancer.

These studies describe risks from exposures occurring from time periods before 1950 up to 1981. Because of the long latency period for lung cancer, exposures after 1970 probably have had limited impact on the reported results. Compared to the levels in the early 1970´s present exposures to arsenic are lower by a factor of ten or more and risks probably correspondingly lower.

Place, publisher, year, edition, pages
Umeå: Folkhälsa och klinisk medicin , 2007. , 86 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1140
Keyword [en]
Copper-lead smelter, lung cancer, lead exposure, arsenic exposure
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-1443ISBN: 978-91-7264-445-8 (print)OAI: oai:DiVA.org:umu-1443DiVA: diva2:141081
Public defence
2007-12-11, Sal B, Tandläkarhögskolan, by 1 D, NUS, Umeå, 09:00 (English)
Opponent
Supervisors
Available from: 2007-11-21 Created: 2007-11-21 Last updated: 2009-06-11Bibliographically approved
List of papers
1. Mortality and lead exposure: a retrospective cohort study of Swedish smelter workers
Open this publication in new window or tab >>Mortality and lead exposure: a retrospective cohort study of Swedish smelter workers
1986 (English)In: British journal of industrial medicine, ISSN 0007-1072, Vol. 43, no 10, 707-712 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-2799 (URN)3778840 (PubMedID)
Available from: 2007-11-21 Created: 2007-11-21Bibliographically approved
2. Cumulative lead exposure: relationship to mortality and lung cancer morbidity in a cohort of smelter workers
Open this publication in new window or tab >>Cumulative lead exposure: relationship to mortality and lung cancer morbidity in a cohort of smelter workers
Show others...
1997 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 23, no 1, 24-30 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-2800 (URN)9098908 (PubMedID)
Available from: 2007-11-21 Created: 2007-11-21 Last updated: 2017-12-14Bibliographically approved
3. Lung cancer risks among lead smelter workers also exposed to arsenic
Open this publication in new window or tab >>Lung cancer risks among lead smelter workers also exposed to arsenic
Show others...
2001 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 273, no 1-3, 77-82 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-2801 (URN)10.1016/S0048-9697(00)00843-3 (DOI)11419604 (PubMedID)
Available from: 2007-11-21 Created: 2007-11-21 Last updated: 2017-12-14Bibliographically approved
4. Lung cancer development in primary smelter workers: a nested case-referent study.
Open this publication in new window or tab >>Lung cancer development in primary smelter workers: a nested case-referent study.
Show others...
2006 (English)In: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 48, no 4, 376-380 p.Article in journal (Refereed) Published
Keyword
Arsenic Poisoning/*epidemiology, Case-Control Studies, Causality, Cohort Studies, Comorbidity, Follow-Up Studies, Humans, Inhalation Exposure/analysis/statistics & numerical data, Lead Poisoning/blood/*epidemiology, Logistic Models, Lung Neoplasms/*epidemiology, Male, Metallurgy/*statistics & numerical data, Models; Statistical, Occupational Diseases/blood/*epidemiology, Occupational Exposure/analysis/statistics & numerical data, Smoking/epidemiology, Survival Analysis, Sweden/epidemiology
Identifiers
urn:nbn:se:umu:diva-5906 (URN)10.1097/01.jom.0000201556.95982.95 (DOI)16607191 (PubMedID)
Available from: 2007-12-07 Created: 2007-12-07 Last updated: 2017-12-14Bibliographically approved

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