Calmodulin dependence of NFκB activation
1998 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 441, no 1, 132-136 p.Article in journal (Refereed) Published
The NF kappa B family of transcription factors is regulated by inhibitory I kappa B proteins. A diversity of stimuli leads to the phosphorylation and subsequent degradation of I kappa B, releasing NF kappa B to act on its target genes. Calmodulin (CaM) is a key regulator of numerous cellular processes and is the predominant intracellular receptor for Ca2+ signals. Here me report that several CaM antagonists inhibit the activation of NF kappa B, and that this is due to the prevention of inducible I kappa B phosphorylation. Our results suggest that CaM is involved in the phosphorylation of I kappa B, a finding that may help in elucidating the mechanism of this critical step of NF kappa B activation.
Place, publisher, year, edition, pages
Elsevier, 1998. Vol. 441, no 1, 132-136 p.
calmodulin, I kappa B, nuclear factor kappa B, phosphorylation, transcriptional regulation
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:umu:diva-3009DOI: 10.1016/S0014-5793(98)01537-3ISI: 000077631800028OAI: oai:DiVA.org:umu-3009DiVA: diva2:141432