Efficient Microwave Assisted Synthesis of Optically Active Bicyclic 2-Pyridinones via Δ2-Thiazolines
2003 (English)In: Molecular diversity, ISSN 1381-1991, E-ISSN 1573-501X, no 2-4, 165-169 p.Article in journal (Refereed) Published
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via 2-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.
Place, publisher, year, edition, pages
Springer Netherlands, 2003. no 2-4, 165-169 p.
cycloaddition, Meldrum's acid, microwave, pyridone, thiazoline, 2-pyridinone
IdentifiersURN: urn:nbn:se:umu:diva-3204DOI: 10.1023/B:MODI.0000006800.46154.99OAI: oai:DiVA.org:umu-3204DiVA: diva2:141703